Trending repositories

1.xiaoyang111222 / cn-math-taxonomy

数学（小学到高中）、英语（三年级到高中）、初中物理的知识图谱：1644 个知识点、2403 条先修边、6723 道题，对齐课标，附自适应前置诊断。

• chinese
• curriculum
• diagnostic
• edtech
• education
• junior-high-school
• +10 more

2.K-Dense-AI / scientific-agent-skills

Turn any AI agent into an AI Scientist. The #1 Agent Skills library for science, used by 250,000+ scientists worldwide. 177 ready-to-use validated skills plus 100+ scientific databases covering biology, chemistry, medicine, and drug discovery. Compatible with Cursor, Claude Code, Codex, Pi, Antigravity, and the open Agent Skills standard.

• ai-scientist
• bioinformatics
• chemoinformatics
• claude
• claude-skills
• claudecode
• +11 more

3.mvanhorn / last30days-skill

AI agent skill that researches any topic across Reddit, X, YouTube, HN, Polymarket, and the web - then synthesizes a grounded summary

• ai-prompts
• claude
• claude-code
• reddit
• twitter
• hackernews
• +14 more

4.ManimCommunity / manim

A community-maintained Python framework for creating mathematical animations.

• math
• python
• manim
• animations
• hacktoberfest

5.PDFMathTranslate / PDFMathTranslate

[EMNLP 2025 Demo] PDF scientific paper translation with preserved formats - 基于 AI 完整保留排版的 PDF 文档全文双语翻译，支持 Google/DeepL/Ollama/OpenAI 等服务，提供 CLI/GUI/MCP/Docker/Zotero

• chinese
• latex
• pdf
• translation
• korean
• english
• +13 more

6.reacher-z / Awesome-CUA

Open, source-backed catalog of computer-use agents: reviewed papers, GUI models, datasets, benchmarks, tools, and reusable JSONL/SQLite data.

• agent-evaluation
• agentic-ai
• ai-agents
• awesome
• awesome-list
• benchmarks
• +14 more

7.microsoft / qlib

Qlib is an AI-oriented Quant investment platform that aims to use AI tech to empower Quant Research, from exploring ideas to implementing productions. Qlib supports diverse ML modeling paradigms, including supervised learning, market dynamics modeling, and RL, and is now equipped with https://github.com/microsoft/RD-Agent to automate R&D process.

• quantitative-finance
• machine-learning
• stock-data
• platform
• finance
• algorithmic-trading
• +12 more

8.Shyboy0499 / precondition-library

An agent that compiles git maintenance chores into reusable programs, then decides whether to replay them by running checks rather than by guessing the task looks familiar

• agent-architecture
• git-automation
• llm-agents
• program-synthesis
• research

9.WenyuChiou / ai-research-skills

Universal SKILL.md catalog for research workflows: literature review, research design, project memory, manuscript writing, and cross-agent delegation for Claude Code, Codex, Gemini, Cursor, OpenClaw, and generic AI clients.

• academic-writing
• ai-skills
• notebooklm
• obsidian
• zotero
• claude-code
• +14 more

10.assafelovic / gpt-researcher

An autonomous agent that conducts deep research on any data using any LLM providers

• ai
• python
• agent
• automation
• research
• search
• +5 more

11.microsoft / RD-Agent

Research and development (R&D) is crucial for the enhancement of industrial productivity, especially in the AI era, where the core aspects of R&D are mainly focused on data and models. We are committed to automating these high-value generic R&D processes through R&D-Agent, which lets AI drive data-driven AI. 🔗https://aka.ms/RD-Agent-Tech-Report

• agent
• ai
• automation
• data-mining
• data-science
• development
• +2 more

12.khoj-ai / khoj

Your AI second brain. Self-hostable. Get answers from the web or your docs. Build custom agents, schedule automations, do deep research. Turn any online or local LLM into your personal, autonomous AI (gpt, claude, gemini, llama, qwen, mistral). Get started - free.

• semantic-search
• emacs
• obsidian-md
• chat
• chatgpt
• ai
• +14 more

13.numpy / numpy

The fundamental package for scientific computing with Python.

• numpy
• python

14.LearningCircuit / local-deep-research

~95% on SimpleQA (e.g. Qwen3.6-27B on a 3090). Supports all local and cloud LLMs (llama.cpp, Ollama, Google, ...). 10+ search engines - arXiv, PubMed, your private documents. Everything Local & Encrypted.

• academia
• arxiv
• brave
• deep-research
• local
• local-llm
• +14 more

15.scikit-learn / scikit-learn

scikit-learn: machine learning in Python

• machine-learning
• python
• statistics
• data-science
• data-analysis

16.ray-project / ray

Ray is an AI compute engine. Ray consists of a core distributed runtime and a set of AI Libraries for accelerating ML workloads.

• ray
• distributed
• parallel
• machine-learning
• reinforcement-learning
• deep-learning
• +14 more

17.mll-lab-nu / embodied-first-exam

The first exam for code agents in the physical world: frozen robot tasks from many benchmark suites, each answered with a program and verified in a separate sandbox. Runs on Harbor.

• ai-agents
• benchmark
• coding-agents
• embodied-ai
• evaluation
• harbor
• +4 more

18.rossant / awesome-math

A curated list of awesome mathematics resources

• awesome-list
• mathematics
• awesome
• lecture-notes
• list

19.astropy / astropy

Astronomy and astrophysics core library

• python
• astronomy
• science
• astrophysics
• astropy

20.future-agi / future-agi

Open-source, end-to-end platform for evaluating, observing, and improving LLM and AI agent applications. Tracing · Evals · Simulations · Datasets · Gateway · Guardrails. Self-hostable. Apache 2.0.

• ai-gateway
• observability
• simulation
• ai-agents
• ai-evals
• evaluation-framework
• +14 more

21.Genesis-Embodied-AI / genesis-world

Simulation platform for general-purpose robotics & embodied AI learning.

22.deepchem / deepchem

Democratizing Deep-Learning for Drug Discovery, Quantum Chemistry, Materials Science and Biology

• drug-discovery
• quantum-chemistry
• deep-learning
• biology
• materials-science
• hacktoberfest

23.bytedance / UI-TARS

Pioneering Automated GUI Interaction with Native Agents

• research

24.scipy / scipy

SciPy library main repository

• python
• scipy
• algorithms
• closember
• scientific-computing

25.statsmodels / statsmodels

Statsmodels: statistical modeling and econometrics in Python

• python
• statistics
• econometrics
• data-analysis
• generalized-linear-models
• timeseries-analysis
• +7 more

26.Qiskit / qiskit

Qiskit is an open-source SDK for working with quantum computers at the level of extended quantum circuits, operators, and primitives.

• quantum-computing
• qiskit
• sdk
• quantum-programming-language
• quantum-circuit
• quantum
• +3 more

27.sympy / sympy

A computer algebra system written in pure Python

• python
• math
• computer-algebra
• science
• hacktoberfest

28.mesa / mesa

Mesa is an open-source Python library for agent-based modeling, ideal for simulating complex systems and exploring emergent behaviors.

• mesa
• agent-based-modeling
• agent-based-simulation
• simulation-framework
• simulation
• simulation-environment
• +5 more

29.X-DataInitiative / tick

Module for statistical learning, with a particular emphasis on time-dependent modelling

• machine-learning
• python
• point-process
• optimization
• modelling
• statistics

30.google / tf-quant-finance

High-performance TensorFlow library for quantitative finance.

• tensorflow
• quantitative-finance
• python
• finance
• numerical-methods
• numerical-optimization
• +6 more

31.Nixtla / statsforecast

Lightning ⚡️ fast forecasting with statistical and econometric models.

• time-series
• statistics
• forecasting
• arima
• econometrics
• machine-learning
• +14 more

32.mostafatouny / awesome-theoretical-computer-science

Math & CS awesome List, distinguished by proof and logic technique

• awesome
• awesome-list
• list
• lists
• theoretical-computer-science
• theory-of-computation
• +2 more

33.biopython / biopython

Official git repository for Biopython (originally converted from CVS)

• python
• bioinformatics
• genomics
• biopython
• protein
• protein-structure
• +3 more

34.quantumlib / Cirq

Python framework for creating, editing, and running Noisy Intermediate-Scale Quantum (NISQ) circuits.

• nisq
• quantum-algorithms
• quantum-computing
• cirq
• algorithms
• api
• +14 more

35.PennyLaneAI / pennylane

PennyLane is an open-source quantum software platform for quantum computing, quantum machine learning, and quantum chemistry. Create meaningful quantum algorithms, from inspiration to implementation.

• quantum
• machine-learning
• deep-learning
• neural-network
• optimization
• quantum-computing
• +12 more

36.OpenMDAO / OpenMDAO

OpenMDAO repository.

• nasa
• open-source
• framework
• openmdao
• optimization

37.eclipse-sumo / sumo

Eclipse SUMO is an open source, highly portable, microscopic and continuous traffic simulation package designed to handle large networks. It allows for intermodal simulation including pedestrians and comes with a large set of tools for scenario creation.

• traffic
• simulation
• transport

38.jslee02 / awesome-robotics-libraries

:sunglasses: A curated list of robotics libraries and software

• robotics-libraries
• multibody-dynamics
• simulation
• robotics
• motion-planning
• slam
• +6 more

39.gcorso / DiffDock

Implementation of DiffDock: Diffusion Steps, Twists, and Turns for Molecular Docking

• diffusion-models
• docking
• binding
• computational-biology
• equivariance
• machine-learning
• +2 more

40.taojy123 / KeymouseGo

类似按键精灵的鼠标键盘录制和自动化操作 模拟点击和键入 | automate mouse clicks and keyboard input

• python
• keyboard
• mouse
• simulation
• automate

41.spack / spack

A flexible package manager that supports multiple versions, configurations, platforms, and compilers.

• python
• spack
• package-manager
• hpc
• build-tools
• radiuss
• +5 more

42.the-dual-space / pymoo

NSGA2, NSGA3, R-NSGA3, MOEAD, Genetic Algorithms (GA), Differential Evolution (DE), CMAES, PSO

• optimization
• multi-objective-optimization
• nsga2
• nsga3
• genetic-algorithm
• differential-evolution
• +2 more

43.Data-Centric-AI-Community / fg-data-profiling

1 Line of code data quality profiling & exploratory data analysis for Pandas and Spark DataFrames.

• pandas-profiling
• pandas-dataframe
• statistics
• jupyter-notebook
• exploration
• data-science
• +14 more

44.Yorko / mlcourse.ai

Open Machine Learning Course

• machine-learning
• data-analysis
• data-science
• pandas
• algorithms
• numpy
• +11 more

45.evo-design / evo

Biological foundation modeling from molecular to genome scale

46.ClawBio / ClawBio

🦖 ClawBio - The first bioinformatics-native AI agent skill library. Local-first. Reproducible. Open. Free.

• ai-agents
• bioinformatics
• equity
• genomics
• local-first
• openclaw
• +2 more

47.mdtraj / mdtraj

An open library for the analysis of molecular dynamics trajectories

• molecular-dynamics
• python
• mdtraj
• rmsd
• dihedral-angles
• pdb
• +2 more

48.plotly / dash

Data Apps & Dashboards for Python. No JavaScript Required.

• dash
• plotly
• data-visualization
• data-science
• gui-framework
• flask
• +12 more

49.mahmoud / boltons

🔩 Like builtins, but boltons. 250+ constructs, recipes, and snippets which extend (and rely on nothing but) the Python standard library. Nothing like Michael Bolton.

• python
• utilities
• cache
• data-structures
• statistics
• data-science
• +5 more

50.nschloe / meshio

:spider_web: input/output for many mesh formats

• vtk
• pypi
• python
• mesh
• mathematics
• engineering
• +1 more

51.microsoft / MarS

MarS: a Financial Market Simulation Engine Powered by Generative Foundation Model

52.indigo-dc / udocker

A basic user tool to execute simple docker containers in batch or interactive systems without root privileges.

• docker
• containers
• batch
• user
• emulation
• proot
• +10 more

53.unknown-horizons / unknown-horizons

Unknown Horizons official code repository

• game
• python
• strategy
• simulation

54.brian-team / brian2

Brian is a free, open source simulator for spiking neural networks.

• python
• neuroscience
• science
• differential-equations
• spiking-neural-networks
• biological-simulations
• +5 more

55.mikamikasuki / forest

FOREST is a research agent for long-horizon science, where evidence gets lost, errors compound, and goals drift. It explores ideas, reads literature, forms hypotheses, runs real experiments, analyzes results, revises paths, and builds a full paper—all in an editable graph you can inspect, branch, redirect, with claims and figures linked to evidence

• ai-agents
• ai-scientist
• automated-research
• autoresearch
• llm-agents
• research

56.hpcaitech / ColossalAI

Making large AI models cheaper, faster and more accessible

• deep-learning
• hpc
• large-scale
• data-parallelism
• pipeline-parallelism
• model-parallelism
• +6 more

57.bayesian-optimization / BayesianOptimization

A Python implementation of global optimization with gaussian processes.

• optimization
• gaussian-processes
• bayesian-optimization
• python
• simple

58.scikit-learn-contrib / imbalanced-learn

A Python Package to Tackle the Curse of Imbalanced Datasets in Machine Learning

• machine-learning
• python
• statistics
• data-science
• data-analysis

59.mikedh / trimesh

Python library for loading and using triangular meshes.

• mesh
• triangular-meshes
• geometry
• python

60.SciTools / cartopy

Cartopy - a cartographic python library with matplotlib support

• cartopy
• matplotlib
• python
• geometry
• maps
• spatial
• +1 more

61.Mariewelt / OpenChem

OpenChem: Deep Learning toolkit for Computational Chemistry and Drug Design Research

• computational-chemistry
• computational-biology
• deep-learning
• deep-neural-networks
• graph-convolutional-networks
• drug-discovery
• +5 more

62.chainer / chainer-chemistry

Chainer Chemistry: A Library for Deep Learning in Biology and Chemistry

• deep-learning
• chemistry
• neural-network
• biology
• chainer
• python
• +1 more

63.ElliotXie / autozyme

Autonomous multi-agent framework to optimize scientific software

• acceleration
• agentic-ai
• ai-agents
• bioinformatics
• code-optimization
• genomics
• +11 more

64.chemprop / chemprop

Message Passing Neural Networks for Molecule Property Prediction

• machine-learning
• chemistry
• neural-networks
• drug-discovery

65.google-deepmind / optax

Optax is a gradient processing and optimization library for JAX.

• machine-learning
• optimization

66.obspy / obspy

ObsPy: A Python Toolbox for seismology/seismological observatories.

• seismology
• python
• observatories
• science
• earthquakes
• data-center
• +5 more

67.dswah / pyGAM

[CONTRIBUTORS WELCOME] Generalized Additive Models in Python

• machine-learning
• data-science
• scientific-computing
• python
• interpretable-machine-learning
• gams
• +5 more

68.nschloe / pygmsh

:spider_web: Gmsh for Python

• python
• pypi
• mesh-generation
• engineering
• mathematics
• meshing

69.usnistgov / fipy

FiPy is a Finite Volume PDE solver written in Python

• scientific-computing
• scientific-computing-with-python
• phase-field
• materials-science
• partial-differential-equations
• shared-memory-parallel
• +2 more

70.BenevolentAI / guacamol

Benchmarks for generative chemistry

71.1105216375-alt / resimind

Neuro-symbolic agents with verified memory. MCP math tools, an algebra repair Skill, and an open challenge. Verify solutions, learn checked rules, and reuse.

• ai-agents
• mathematics
• neuro-symbolic
• reasoning
• verification
• residual-reasoning
• +14 more

72.guofei9987 / scikit-opt

Genetic Algorithm, Particle Swarm Optimization, Simulated Annealing, Ant Colony Optimization Algorithm,Immune Algorithm, Artificial Fish Swarm Algorithm, Differential Evolution and TSP(Traveling salesman)

• genetic-algorithm
• pso
• particle-swarm-optimization
• tsp
• travelling-salesman-problem
• simulated-annealing
• +7 more

73.pgmpy / pgmpy

Python Toolkit for Causal and Probabilistic Reasoning

• python
• bayesian-networks
• causal-inference
• causal-discovery
• causal-identification
• causal-models
• +9 more

74.ahmedfgad / GeneticAlgorithmPython

Source code of PyGAD, a Python 3 library for building the genetic algorithm and training machine learning algorithms (Keras & PyTorch).

• python
• genetic-algorithm
• optimization
• numpy
• pygad
• pygad-documentation
• +4 more

75.dmis-lab / biobert

Bioinformatics'2020: BioBERT: a pre-trained biomedical language representation model for biomedical text mining

76.qutip / qutip

QuTiP: Quantum Toolbox in Python

• qutip
• python
• quantum-toolbox
• quantum
• quantum-computing
• quantum-mechanics
• +3 more

77.allenai / scispacy

A full spaCy pipeline and models for scientific/biomedical documents.

• scientific-documents
• spacy
• custom-pipes
• nlp
• biomedical
• bioinformatics

78.ucla-mobility / OpenCDA

A generalized framework for prototyping full-stack cooperative driving automation applications under CARLA+SUMO.

• autonomous-driving
• cooperative-driving-automation
• simulation
• connected-and-automated-vehicles
• automated-driving-systems

79.hail-is / hail

Cloud-native genomic dataframes and batch computing

• genetics
• vcf
• genomics
• gwas
• bioinformatics
• python
• +2 more

80.molecularsets / moses

Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models

• machine-learning
• generative-models
• drug-discovery
• benchmark

81.uuvsimulator / uuv_simulatorArchived

Gazebo/ROS packages for underwater robotics simulation

• gazebo
• simulation
• ros
• underwater
• robotics-simulation
• rov
• +3 more

82.danforthcenter / plantcv

Plant phenotyping with image analysis

• science
• bioinformatics
• image-analysis
• plant-phenotyping
• plantcv

83.dib-lab / khmer

In-memory nucleotide sequence k-mer counting, filtering, graph traversal and more

• dna
• k-mer
• python
• bloom-filter
• count-min-sketch
• graph-traversal
• +1 more

84.brainglobe / brainrender

A Python package to visualise neuroanatomical data in atlas space

• neuroscience
• python
• anatomy
• visualization

85.TUDelft-CNS-ATM / bluesky

The open source air traffic simulator

• python
• traffic
• aircraft
• simulation
• air-traffic-control
• air-transport
• +11 more

86.aeturrell / skimpy

skimpy is a light weight tool that provides summary statistics about variables in data frames within the console.

• eda
• pandas
• data-science
• exploratory-data-analysis
• summary-statistics
• statistics

87.pathsim / pathsim

A Python native dynamical system simulation framework in the block diagram paradigm.

• blockdiagram
• control-systems
• hierarchical-modeling
• nonlinear-dynamics
• simulation
• system-simulation
• +14 more

88.gao-lab / GLUE

Graph-linked unified embedding for single-cell multi-omics data integration

• bioinformatics
• deep-learning
• single-cell
• single-cell-multiomics

89.cclib / cclib

Parsers and algorithms for computational chemistry logfiles

• python
• computational-chemistry
• quantum-chemistry

90.pydy / pydy

Multibody dynamics tool kit.

• python
• dynamics
• physics
• simulation

91.maximtrp / scikit-posthocs

Multiple Pairwise Comparisons (Post Hoc) Tests in Python

• posthoc-comparisons
• posthoc-tests
• python
• scikit
• statistical-analysis
• statistics
• +1 more

92.mdolab / OpenAeroStruct

OpenAeroStruct is a lightweight tool that performs aerostructural optimization using OpenMDAO.

• openmdao
• optimization
• aerodynamics
• open-source

93.bp-kelley / descriptastorus

Descriptor computation(chemistry) and (optional) storage for machine learning

94.MLT-OSS / FirstData

The World's Most Comprehensive, Authoritative, and Structured Open Source Data Source Knowledge Base

• mcp
• data-sources
• ai
• awesome-list
• datasets
• fact-checking
• +14 more

95.kreshuklab / panseg

A tool for cell instance aware segmentation in densely packed 3D volumetric images

• segmentation
• deep-learning
• bioinformatics
• neural-network
• bioimage-analysis
• image-segmentation
• +1 more

96.marcpinet / citracer

💬 Trace citation chains for any concept across research papers and render them as an interactive graph.

• academic-research
• bibliography
• citation-graph
• cli
• grobid
• literature-review
• +5 more

97.cafferychen777 / flashdeconv

Fast, deterministic cell-type deconvolution for million-bin spatial transcriptomics

• bioinformatics
• cell-type-deconvolution
• computational-biology
• deconvolution
• python
• scanpy
• +3 more