1.deepchem / deepchem
Democratizing Deep-Learning for Drug Discovery, Quantum Chemistry, Materials Science and Biology
- drug-discovery
- quantum-chemistry
- deep-learning
- biology
- materials-science
- hacktoberfest
+228 stars
from 6,895 · score 5.43
Trending repositories
Ranked by Attention Score: stars gained over the last 90 complete days
25 repositories by Attention Score · Aug 7, 2026 – Nov 4, 2026 (UTC)
2.jwohlwend / boltz
Official repository for the Boltz biomolecular interaction models
- binding-prediction
- drug-discovery
- protein-structure
+159 stars
from 4,133 · score 5.08
+86 stars
from 1,813 · score 4.47
+56 stars
from 1,606 · score 4.04
+55 stars
from 2,227 · score 4.03
6.mims-harvard / PrimeKG
Precision Medicine Knowledge Graph (PrimeKG)
- knowledge-graph
- precision-medicine
- therapeutics
- bioinformatics
- dataset
- graph-machine-learning
- +2 more
+37 stars
from 801 · score 3.64
7.songlab-cal / gpn
Genomic Pretrained Network - GPN, GPN-MSA, PhyloGPN, GPN-Star
- dna
- language-model
- variant-effect-prediction
- genomics
+37 stars
from 350 · score 3.64
8.RosettaCommons / RoseTTAFold
This package contains deep learning models and related scripts for RoseTTAFold
+35 stars
from 2,247 · score 3.58
9.snap-stanford / GEARS
GEARS is a geometric deep learning model that predicts outcomes of novel multi-gene perturbations
+33 stars
from 389 · score 3.53
10.snap-stanford / UCE
UCE is a zero-shot foundation model for single-cell gene expression data
+29 stars
from 322 · score 3.40
11.OATML-Markslab / ProteinGym
Official repository for the ProteinGym benchmarks
- benchmark
- computational-biology
- protein
- protein-design
- protein-fitness
+28 stars
from 456 · score 3.37
12.Teichlab / celltypist
A tool for semi-automatic cell type classification
- python
- single-cell
- machine-learning
- scrna-seq
- cell-type-classification
- label-transfer
+17 stars
from 500 · score 2.89
13.facebookresearch / esmArchived
Evolutionary Scale Modeling (esm): Pretrained language models for proteins
+16 stars
from 4,160 · score 2.83
14.hail-is / hail
Cloud-native genomic dataframes and batch computing
- genetics
- vcf
- genomics
- gwas
- bioinformatics
- python
- +2 more
+14 stars
from 1,068 · score 2.71
15.microsoft / evodiff
Generation of protein sequences and evolutionary alignments via discrete diffusion models
- discrete-diffusion
- generative-model
- multiple-sequence-alignment
- protein-sequences
+13 stars
from 676 · score 2.64
16.gao-lab / GLUE
Graph-linked unified embedding for single-cell multi-omics data integration
- bioinformatics
- deep-learning
- single-cell
- single-cell-multiomics
+13 stars
from 473 · score 2.64
17.Martinsos / edlib
Lightweight, super fast C/C++ (& Python) library for sequence alignment using edit (Levenshtein) distance.
- sequence-alignment
- edit-distance
- levehnstein-distance
- library
- c-plus-plus
- alignment-path
- +2 more
+10 stars
from 602 · score 2.40
+10 stars
from 425 · score 2.40
19.agemagician / ProtTrans
ProtTrans is providing state of the art pretrained language models for proteins. ProtTrans was trained on thousands of GPUs from Summit and hundreds of Google TPUs using Transformers Models.
+9 stars
from 1,314 · score 2.30
20.vcflib / vcflib
C++ library and cmdline tools for parsing and manipulating VCF files with python and zig bindings
- variant-calling
- genomics
- vcf-manipulation
- genotyping
- haplotypecaller
+8 stars
from 681 · score 2.20
21.shenwei356 / taxonkit
A Practical and Efficient NCBI Taxonomy Toolkit, also supports creating NCBI-style taxdump files for custom taxonomies like GTDB/ICTV
- bioinformatics
- taxonomy
- cross-platform
- lineage
- lca
- taxid
- +2 more
+8 stars
from 476 · score 2.20
22.snap-stanford / SATURN
The repository host gives no description.
+7 stars
from 169 · score 2.08
23.bebop / poly
A Go package for engineering organisms.
- synthetic-biology
- synbio
- genetic-engineering
- molecular-biology
- bioengineering
- computational-biology
- +14 more
+5 stars
from 731 · score 1.79
24.OpenBioLink / OpenBioLink
OpenBioLink is a resource and evaluation framework for evaluating link prediction models on heterogeneous biomedical graph data.
+3 stars
from 161 · score 1.39
25.bcbio / bcbio-nextgen
Validated, scalable, community developed variant calling, RNA-seq and small RNA analysis
+2 stars
from 1,028 · score 1.10