+1,286 stars
from 27,757 · score 7.16
Trending repositories
Ranked by Attention Score: stars gained over the last 90 complete days
1–100 of 162 by Attention Score · Aug 6, 2026 – Nov 3, 2026 (UTC)
2.PavelDoGreat / WebGL-Fluid-Simulation
Play with fluids in your browser (works even on mobile)
- fluid
- webgl
- simulation
- gpu
- navier-stokes
+302 stars
from 16,496 · score 5.71
3.boyter / scc
Sloc, Cloc and Code: scc is a very fast accurate code counter with complexity calculations and COCOMO estimates written in pure Go
+287 stars
from 8,570 · score 5.66
4.deepchem / deepchem
Democratizing Deep-Learning for Drug Discovery, Quantum Chemistry, Materials Science and Biology
- drug-discovery
- quantum-chemistry
- deep-learning
- biology
- materials-science
- hacktoberfest
+232 stars
from 6,891 · score 5.45
+190 stars
from 12,200 · score 5.25
6.jwohlwend / boltz
Official repository for the Boltz biomolecular interaction models
- binding-prediction
- drug-discovery
- protein-structure
+156 stars
from 4,133 · score 5.06
7.OHIF / Viewers
OHIF zero-footprint DICOM viewer and oncology specific Lesion Tracker, plus shared extension packages
- nci-itcr
- nci-qin
- quantitative-imaging
- imaging-informatics
- cancer-imaging-research
- dicom
- +10 more
+129 stars
from 4,267 · score 4.87
8.pyvista / pyvista
3D visualization and mesh analysis for science and engineering
- vtk
- python
- visualization
- 3d
- meshviewer
- scientific-visualization
- +6 more
+128 stars
from 3,747 · score 4.86
9.guofei9987 / scikit-opt
Genetic Algorithm, Particle Swarm Optimization, Simulated Annealing, Ant Colony Optimization Algorithm,Immune Algorithm, Artificial Fish Swarm Algorithm, Differential Evolution and TSP(Traveling salesman)
- genetic-algorithm
- pso
- particle-swarm-optimization
- tsp
- travelling-salesman-problem
- simulated-annealing
- +7 more
+124 stars
from 6,602 · score 4.83
10.Turfjs / turf
A modular geospatial engine written in JavaScript and TypeScript
- javascript
- algorithm
- computational-geometry
- geojson
- turf
- gis
- +3 more
+117 stars
from 10,414 · score 4.77
11.pathsim / pathsim
A Python native dynamical system simulation framework in the block diagram paradigm.
- blockdiagram
- control-systems
- hierarchical-modeling
- nonlinear-dynamics
- simulation
- system-simulation
- +14 more
+103 stars
from 409 · score 4.64
+86 stars
from 1,812 · score 4.47
13.mikedh / trimesh
Python library for loading and using triangular meshes.
- mesh
- triangular-meshes
- geometry
- python
+85 stars
from 3,630 · score 4.45
+69 stars
from 3,575 · score 4.25
+57 stars
from 1,606 · score 4.06
+56 stars
from 2,781 · score 4.04
17.bayesian-optimization / BayesianOptimization
A Python implementation of global optimization with gaussian processes.
- optimization
- gaussian-processes
- bayesian-optimization
- python
- simple
+55 stars
from 8,674 · score 4.03
+54 stars
from 2,227 · score 4.01
19.zarr-developers / zarr-python
An implementation of chunked, compressed, N-dimensional arrays for Python.
- zarr
- ndimensional-arrays
- compressed
- python
+51 stars
from 2,029 · score 3.95
20.MFlowCode / MFC
Exascale multiphase flow solver — 2025 Gordon Bell Prize Finalist | 200T grid points on 43K+ GPUs
+49 stars
from 390 · score 3.91
21.gcorso / DiffDock
Implementation of DiffDock: Diffusion Steps, Twists, and Turns for Molecular Docking
- diffusion-models
- docking
- binding
- computational-biology
- equivariance
- machine-learning
- +2 more
+46 stars
from 1,553 · score 3.85
22.HIPS / autograd
Efficiently computes derivatives of NumPy code.
- autograd
- automatic-differentiation
- numpy
- python
- deep-learning
- derivative
- +8 more
+41 stars
from 7,510 · score 3.74
23.deepmodeling / Uni-Mol
Official Repository for the Uni-Mol Series Methods
- molecular-modeling
- pre-trained-model
- pretraining
- deep-learning
+40 stars
from 1,136 · score 3.71
24.aidenybai / million
Optimizing compiler for React
- hacktoberfest
- million
- millionjs
- virtual-dom
- react
- blockdom
- +11 more
+39 stars
from 17,624 · score 3.69
25.songlab-cal / gpn
Genomic Pretrained Network - GPN, GPN-MSA, PhyloGPN, GPN-Star
- dna
- language-model
- variant-effect-prediction
- genomics
+38 stars
from 349 · score 3.66
26.mims-harvard / PrimeKG
Precision Medicine Knowledge Graph (PrimeKG)
- knowledge-graph
- precision-medicine
- therapeutics
- bioinformatics
- dataset
- graph-machine-learning
- +2 more
+37 stars
from 801 · score 3.64
27.microsoft / DirectXMath
DirectXMath is an all inline SIMD C++ linear algebra library for use in games and graphics apps
+36 stars
from 1,780 · score 3.61
28.PythonOT / POT
POT : Python Optimal Transport
- optimal-transport
- numerical-optimization
- machine-learning
- emd
- ot-mapping-estimation
- wasserstein-barycenter
- +10 more
+33 stars
from 2,827 · score 3.53
29.RosettaCommons / RoseTTAFold
This package contains deep learning models and related scripts for RoseTTAFold
+33 stars
from 2,247 · score 3.53
30.brick / math
Arbitrary-precision arithmetic library for PHP
- php
- arbitrary-precision
- biginteger
- bigdecimal
- bigrational
- gmp
- +1 more
+33 stars
from 2,147 · score 3.53
31.paulmillr / noble-post-quantum
Auditable & minimal JS implementation of public-key post-quantum cryptography
- dilithium
- kyber
- ml-kem
- post-quantum-cryptography
- sphincs
- sphincs-plus
- +14 more
+33 stars
from 337 · score 3.53
32.TUDelft-CNS-ATM / bluesky
The open source air traffic simulator
- python
- traffic
- aircraft
- simulation
- air-traffic-control
- air-transport
- +11 more
+29 stars
from 546 · score 3.40
33.zoharbabin / web-researcher-mcp
Search the web and primary sources, read full pages, and check every citation. MCP server for Claude, Cursor, Codex and more. Runs on your machine.
+29 stars
from 47 · score 3.40
34.OATML-Markslab / ProteinGym
Official repository for the ProteinGym benchmarks
- benchmark
- computational-biology
- protein
- protein-design
- protein-fitness
+28 stars
from 456 · score 3.37
35.ikpil / Box2D.NET
Box2D.NET - a C# port of Box2D, is a 2D physics engine for games, .NET, Unity3D, servers
- 2d
- 2d-game
- box2d
- csharp
- game
- game-development
- +8 more
+28 stars
from 198 · score 3.37
36.DavidArayan / ezy-slice
An open source mesh slicer framework for Unity3D Game Engine. Written in C#.
+25 stars
from 2,256 · score 3.26
+24 stars
from 3,750 · score 3.22
38.Aceinna / gnss-ins-sim
Open-source GNSS + inertial navigation, sensor fusion simulator. Motion trajectory generator, sensor models, and navigation
- inertial-navigation-systems
- gnss
- gps
- imu
- integrated-navigation
+24 stars
from 1,474 · score 3.22
39.suyashkumar / dicom
⚡High Performance DICOM Medical Image Parser in Go.
- dicom
- dicom-images
- golang
- golang-library
- golang-package
- parser
- +10 more
+24 stars
from 1,072 · score 3.22
40.DTolm / VkFFT
Vulkan/CUDA/HIP/OpenCL/Level Zero/Metal Fast Fourier Transform library
+23 stars
from 1,764 · score 3.18
41.vqdang / hover_net
Simultaneous Nuclear Instance Segmentation and Classification in H&E Histology Images.
+23 stars
from 733 · score 3.18
42.pydata / numexpr
Fast numerical array expression evaluator for Python, NumPy, Pandas, PyTables and more
+22 stars
from 2,523 · score 3.14
43.PyWavelets / pywt
PyWavelets - Wavelet Transforms in Python
- wavelets
- wavelet-transform
- signal-processing
- image-processing
- continuous-wavelet
+22 stars
from 2,390 · score 3.14
44.dpilger26 / NumCpp
C++ implementation of the Python Numpy library
- python
- numpy
- c-plus-plus
- numerical-analysis
- scientific-computing
- algorithms
- +3 more
+21 stars
from 3,948 · score 3.09
45.arneschneuing / DiffSBDD
A Euclidean diffusion model for structure-based drug design.
- ddpm
- drug-design
- equivariance
- generative-model
- graph-neural-networks
- machine-learning
+19 stars
from 518 · score 3.00
46.marcomusy / vedo
A python module for scientific analysis of 3D data based on VTK and Numpy
- 3d-graphics
- vtk
- 3d
- mesh
- simulations
- scientific-visualization
- +5 more
+18 stars
from 2,257 · score 2.94
47.autodiff / autodiff
automatic differentiation made easier for C++
- automatic-differentiation
- auto-differentiation
- autodiff
- autodifferentiation
- differentiation
- derivatives
- +1 more
+17 stars
from 1,946 · score 2.89
48.Teichlab / celltypist
A tool for semi-automatic cell type classification
- python
- single-cell
- machine-learning
- scrna-seq
- cell-type-classification
- label-transfer
+17 stars
from 500 · score 2.89
49.facebookresearch / esmArchived
Evolutionary Scale Modeling (esm): Pretrained language models for proteins
+16 stars
from 4,159 · score 2.83
50.pmp-library / pmp-library
The Polygon Mesh Processing Library
- mesh-processing
- geometry-processing
- polygon-mesh
- triangle-mesh
- c-plus-plus
- surface-mesh
- +9 more
+15 stars
from 1,495 · score 2.77
51.owlbarn / owl
Owl - OCaml Scientific Computing @ https://ocaml.xyz
- matrix
- linear-algebra
- ndarray
- statistical-functions
- topic-modeling
- regression
- +14 more
+15 stars
from 1,343 · score 2.77
52.ElliotXie / autozyme
Autonomous multi-agent framework to optimize scientific software
- acceleration
- agentic-ai
- ai-agents
- bioinformatics
- code-optimization
- genomics
- +11 more
+15 stars
from 42 · score 2.77
53.hail-is / hail
Cloud-native genomic dataframes and batch computing
- genetics
- vcf
- genomics
- gwas
- bioinformatics
- python
- +2 more
+14 stars
from 1,068 · score 2.71
+14 stars
from 724 · score 2.71
55.microsoft / evodiff
Generation of protein sequences and evolutionary alignments via discrete diffusion models
- discrete-diffusion
- generative-model
- multiple-sequence-alignment
- protein-sequences
+14 stars
from 676 · score 2.71
56.softwareQinc / qpp
Modern C++ quantum computing library
- quantum-computing
- c-plus-plus
- cpp
- cpp11
- quantum
- simulator
- +2 more
+14 stars
from 664 · score 2.71
57.chainer / chainer-chemistry
Chainer Chemistry: A Library for Deep Learning in Biology and Chemistry
- deep-learning
- chemistry
- neural-network
- biology
- chainer
- python
- +1 more
+13 stars
from 702 · score 2.64
58.brandon-rhodes / python-sgp4
Python version of the SGP4 satellite position library
+13 stars
from 468 · score 2.64
59.MikeMcl / bignumber.js
A JavaScript library for arbitrary-precision decimal and non-decimal arithmetic
- bignumber
- javascript
- arbitrary-precision
- decimal-places
- bigdecimal
+12 stars
from 7,001 · score 2.56
60.Habrador / Computational-geometry
Computational Geometry Unity library with implementations of intersection algorithms, triangulations like delaunay, voronoi diagrams, polygon clipping, bezier curves, ear clipping, convex hulls, mesh simplification, etc
- unity3d
- computational-geometry
- voronoi
- intersections
- convex-hull
- polygon-clipping
- +14 more
+12 stars
from 1,460 · score 2.56
61.molecularsets / moses
Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models
- machine-learning
- generative-models
- drug-discovery
- benchmark
+12 stars
from 985 · score 2.56
62.ddemidov / amgcl
C++ library for solving large sparse linear systems with algebraic multigrid method
- amg
- c-plus-plus
- sparse-linear-systems
- opencl
- cuda
- gpgpu
- +6 more
+12 stars
from 873 · score 2.56
63.spatie / laravel-analytics
A Laravel package to retrieve pageviews and other data from Google Analytics
- laravel
- php
- analytics
- statistics
+11 stars
from 3,233 · score 2.48
64.msteinbeck / tinyspline
ANSI C library for NURBS, B-Splines, and Bézier curves with interfaces for C++, C#, D, Go, Java, Javascript, Lua, Octave, PHP, Python, R, and Ruby.
- nurbs
- b-splines
- bezier-curves
- splines
+11 stars
from 1,347 · score 2.48
65.gao-lab / GLUE
Graph-linked unified embedding for single-cell multi-omics data integration
- bioinformatics
- deep-learning
- single-cell
- single-cell-multiomics
+11 stars
from 473 · score 2.48
66.MLT-OSS / FirstData
The World's Most Comprehensive, Authoritative, and Structured Open Source Data Source Knowledge Base
- mcp
- data-sources
- ai
- awesome-list
- datasets
- fact-checking
- +14 more
+11 stars
from 175 · score 2.48
67.marcpinet / citracer
💬 Trace citation chains for any concept across research papers and render them as an interactive graph.
- academic-research
- bibliography
- citation-graph
- cli
- grobid
- literature-review
- +5 more
+11 stars
from 28 · score 2.48
68.ljvmiranda921 / pyswarms
A research toolkit for particle swarm optimization in Python
- particle-swarm-optimization
- optimization-tools
- pso
- global-optimization
- swarm-intelligence
- machine-learning
- +5 more
+10 stars
from 1,391 · score 2.40
69.ASC-Community / AngouriMath
Open-source cross-platform symbolic algebra library for C# and F#. Can be used for both production and research purposes.
+10 stars
from 822 · score 2.40
70.pyamg / pyamg
Algebraic Multigrid Solvers in Python
- amg
- solver
- python
- multigrid
- sparse-matrix
- pyamg
- +2 more
+10 stars
from 652 · score 2.40
71.Martinsos / edlib
Lightweight, super fast C/C++ (& Python) library for sequence alignment using edit (Levenshtein) distance.
- sequence-alignment
- edit-distance
- levehnstein-distance
- library
- c-plus-plus
- alignment-path
- +2 more
+10 stars
from 602 · score 2.40
+10 stars
from 527 · score 2.40
73.markrogoyski / math-php
Powerful modern math library for PHP: Features descriptive statistics and regressions; Continuous and discrete probability distributions; Linear algebra with matrices and vectors, Numerical analysis; special mathematical functions; Algebra
- math
- mathematics
- linear-algebra
- statistics
- matrix
- probability
- +11 more
+9 stars
from 2,406 · score 2.30
74.giacomelli / GeneticSharp
GeneticSharp is a fast, extensible, multi-platform and multithreading C# Genetic Algorithm library that simplifies the development of applications using Genetic Algorithms (GAs).
- genetic-algorithms
- artificial-intelligence
- c-sharp
- dotnet
- dotnet-core
- dotnet-standard
- +3 more
+9 stars
from 1,367 · score 2.30
75.agemagician / ProtTrans
ProtTrans is providing state of the art pretrained language models for proteins. ProtTrans was trained on thousands of GPUs from Summit and hundreds of Google TPUs using Transformers Models.
+9 stars
from 1,314 · score 2.30
76.Mariewelt / OpenChem
OpenChem: Deep Learning toolkit for Computational Chemistry and Drug Design Research
- computational-chemistry
- computational-biology
- deep-learning
- deep-neural-networks
- graph-convolutional-networks
- drug-discovery
- +5 more
+9 stars
from 750 · score 2.30
77.tequilahub / tequila
A High-Level Abstraction Framework for Quantum Algorithms
+9 stars
from 434 · score 2.30
78.peterstace / simplefeatures
Simple Features is a pure Go Implementation of the OpenGIS Simple Feature Access Specification
+9 stars
from 166 · score 2.30
79.ElliotXie / CASSIA
CASSIA: A Multi-Agent LLM-Based Single-Cell Cell Type Annotation Framework
- ai4science
- llm
- multiagent-systems
- prompt-engineering
- retrieved-augmented-generation
- singlecell
- +7 more
+9 stars
from 100 · score 2.30
80.clean-css / clean-css
Fast and efficient CSS optimizer for node.js and the Web
- css
- minification
- optimization
- css-optimizations
- css-optimizer
- clean-css
+8 stars
from 4,191 · score 2.20
81.vcflib / vcflib
C++ library and cmdline tools for parsing and manipulating VCF files with python and zig bindings
- variant-calling
- genomics
- vcf-manipulation
- genotyping
- haplotypecaller
+8 stars
from 681 · score 2.20
82.shenwei356 / taxonkit
A Practical and Efficient NCBI Taxonomy Toolkit, also supports creating NCBI-style taxdump files for custom taxonomies like GTDB/ICTV
- bioinformatics
- taxonomy
- cross-platform
- lineage
- lca
- taxid
- +2 more
+8 stars
from 476 · score 2.20
83.MolSSI / cookiecutter-cms
Python-centric Cookiecutter for Molecular Computational Chemistry Packages
- cookiecutter
- python-packages
- molecular-sciences
- conda-environment
- pytest
- conda-forge
- +2 more
+8 stars
from 457 · score 2.20
84.fbcosentino / godot-simplified-flightsim
Simplified Flight Simulation library (addon) for Godot Engine
+8 stars
from 302 · score 2.20
85.kreshuklab / panseg
A tool for cell instance aware segmentation in densely packed 3D volumetric images
- segmentation
- deep-learning
- bioinformatics
- neural-network
- bioimage-analysis
- image-segmentation
- +1 more
+8 stars
from 129 · score 2.20
86.kjkrol / goke
High-performance, zero-allocation ECS for Go. Cache-friendly data orchestrator with type-safe iterators.
- ecs
- entity-component-system
- gamedev
- go
- goalng
- geme-engine
- +2 more
+8 stars
from 86 · score 2.20
87.kzampog / cilantro
A lean C++ library for working with point cloud data
- point-cloud
- icp
- ransac
- convex-hull
- 3d-visualization
- k-means
- +14 more
+7 stars
from 1,132 · score 2.08
88.rawify / Fraction.js
The RAW rational numbers library written in JavaScript
- fraction
- javascript
- math
- rational-numbers
- numbers
+7 stars
from 688 · score 2.08
89.vlang / vtl
The V Tensor Library
- v
- hacktoberfest
- autograd
- deep-learning
- linear-algebra
- machine-learning
- +5 more
+7 stars
from 165 · score 2.08
90.theislab / chemCPA
Code for "Predicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution", NeurIPS 2022.
- disentanglement
- drug-discovery
- genomics
- perturbation
- single-cell
- transfer-learning
+7 stars
from 155 · score 2.08
91.erayzesen / QuarkPhysics
A 2D Soft Body and Rigid Body Physics Engine.
- 2d-physics-engine
- game-development
- physics-engine
- rigid-bodies
- soft-bodies
- physics-simulation
+6 stars
from 294 · score 1.95
92.juan-leon / lowcharts
Tool to draw low-resolution graphs in terminal
- plot
- shell
- troubleshooting
- log
- analysis
- command-line
- +2 more
+6 stars
from 249 · score 1.95
93.mojaie / MolecularGraph.jl
Graph-based molecule modeling toolkit for cheminformatics
- cheminformatics
- molecular-modeling
- chemistry
- toolkit
- julia
- julia-language
- +3 more
+6 stars
from 225 · score 1.95
94.sustainable-processes / summit
Optimising chemical reactions using machine learning
- chemistry
- machine-learning
- optimization
- bayesian-optimization
- neural-networks
- drug-discovery
- +4 more
+6 stars
from 149 · score 1.95
+5 stars
from 813 · score 1.79
96.bebop / poly
A Go package for engineering organisms.
- synthetic-biology
- synbio
- genetic-engineering
- molecular-biology
- bioengineering
- computational-biology
- +14 more
+5 stars
from 731 · score 1.79
97.seyonechithrananda / bert-loves-chemistry
bert-loves-chemistry: a repository of HuggingFace models applied on chemical SMILES data for drug design, chemical modelling, etc.
- huggingface
- bert
- chemical-modelling
- chemical-smiles-data
+5 stars
from 498 · score 1.79
98.vlang / vsl
V library to develop Artificial Intelligence and High-Performance Scientific Computations
- v
- hacktoberfest
- linear-algebra
- optimization
- sparse-systems
- computational-geometry
- +7 more
+5 stars
from 400 · score 1.79
99.maximtrp / scikit-posthocs
Multiple Pairwise Comparisons (Post Hoc) Tests in Python
- posthoc-comparisons
- posthoc-tests
- python
- scikit
- statistical-analysis
- statistics
- +1 more
+5 stars
from 386 · score 1.79
100.MaxHalford / eaopt
:four_leaf_clover: Evolutionary optimization library for Go (genetic algorithm, partical swarm optimization, differential evolution)
- go
- optimization
- parallel
- machine-learning
- genetic-algorithm
- speciation
- +5 more
+4 stars
from 903 · score 1.61