101.Reference-LAPACK / lapack
LAPACK development repository
- linear-algebra
- lapack
- blas
- lapacke
- linear-equations
- eigenvalues
- +4 more
+43 stars
from 1,875 · score 3.78
Trending repositories
Ranked by Attention Score: stars gained over the last 90 complete days
101–200 of 548 by Attention Score · Aug 7, 2026 – Nov 4, 2026 (UTC)
102.HIPS / autograd
Efficiently computes derivatives of NumPy code.
- autograd
- automatic-differentiation
- numpy
- python
- deep-learning
- derivative
- +8 more
+42 stars
from 7,510 · score 3.76
+41 stars
from 6,416 · score 3.74
104.mborgerding / kissfft
a Fast Fourier Transform (FFT) library that tries to Keep it Simple, Stupid
+40 stars
from 1,966 · score 3.71
105.aidenybai / million
Optimizing compiler for React
- hacktoberfest
- million
- millionjs
- virtual-dom
- react
- blockdom
- +11 more
+39 stars
from 17,624 · score 3.69
106.deepmodeling / Uni-Mol
Official Repository for the Uni-Mol Series Methods
- molecular-modeling
- pre-trained-model
- pretraining
- deep-learning
+39 stars
from 1,136 · score 3.69
107.stevengj / nlopt
library for nonlinear optimization, wrapping many algorithms for global and local, constrained or unconstrained, optimization
+38 stars
from 2,250 · score 3.66
108.3dmol / 3Dmol.js
WebGL accelerated JavaScript molecular graphics library
- molecular-graphics
- molecular-modeling
- computational-biology
- computational-chemistry
+38 stars
from 998 · score 3.66
109.mahmoodlab / UNI
Pathology Foundation Model - Nature Medicine
- foundation
- foundation-model
- histopathology
- mahmoodlab
- pathology
- uni
- +11 more
+38 stars
from 759 · score 3.66
110.chaidiscovery / chai-lab
Chai-1, SOTA model for biomolecular structure prediction
+37 stars
from 1,971 · score 3.64
111.mims-harvard / PrimeKG
Precision Medicine Knowledge Graph (PrimeKG)
- knowledge-graph
- precision-medicine
- therapeutics
- bioinformatics
- dataset
- graph-machine-learning
- +2 more
+37 stars
from 801 · score 3.64
112.songlab-cal / gpn
Genomic Pretrained Network - GPN, GPN-MSA, PhyloGPN, GPN-Star
- dna
- language-model
- variant-effect-prediction
- genomics
+37 stars
from 350 · score 3.64
113.microsoft / DirectXMath
DirectXMath is an all inline SIMD C++ linear algebra library for use in games and graphics apps
+36 stars
from 1,780 · score 3.61
114.mlmed / torchxrayvision
TorchXRayVision: A library of chest X-ray datasets and models. Classifiers, segmentation, and autoencoders.
- medical-imaging
- medical-ai
- deep-learning
- machine-learning
- transfer-learning
- dataset
- +13 more
+36 stars
from 1,179 · score 3.61
115.simbody / simbody
High-performance C++ multibody dynamics/physics library for simulating articulated biomechanical and mechanical systems like vehicles, robots, and the human skeleton.
- multibody-dynamics
- physics-engine
- physics-simulation
- robotics
- biomechanics
+35 stars
from 2,534 · score 3.58
116.RosettaCommons / RoseTTAFold
This package contains deep learning models and related scripts for RoseTTAFold
+35 stars
from 2,247 · score 3.58
117.FFTW / fftw3
DO NOT CHECK OUT THESE FILES FROM GITHUB UNLESS YOU KNOW WHAT YOU ARE DOING. (See below.)
+34 stars
from 3,078 · score 3.56
118.flame / blis
BLAS-like Library Instantiation Software Framework
- blis
- blas
- blas-libraries
- linear-algebra
- linear-algebra-library
- matrix-multiplication
- +8 more
+34 stars
from 2,664 · score 3.56
119.precice / precice
A coupling library and ecosystem for partitioned multi-physics and multi-scale simulations, including surface and volume coupling.
- multi-physics
- fluid-structure-interaction
- high-performance-computing
- conjugate-heat-transfer
- coupling
- co-simulation
- +13 more
+34 stars
from 953 · score 3.56
120.instadeepai / nucleotide-transformer
Foundation Models for Genomics & Transcriptomics
- genomics
- deep-learning
- transformer
- dna
- foundation-models
- transcriptomics
- +1 more
+34 stars
from 903 · score 3.56
121.hjwdzh / QuadriFlow
QuadriFlow: A Scalable and Robust Method for Quadrangulation
- quadriflow
- quad
- remeshing
- quadrangulation
- geometry
+34 stars
from 848 · score 3.56
122.PythonOT / POT
POT : Python Optimal Transport
- optimal-transport
- numerical-optimization
- machine-learning
- emd
- ot-mapping-estimation
- wasserstein-barycenter
- +10 more
+33 stars
from 2,827 · score 3.53
+33 stars
from 1,738 · score 3.53
124.snap-stanford / GEARS
GEARS is a geometric deep learning model that predicts outcomes of novel multi-gene perturbations
+33 stars
from 389 · score 3.53
125.brick / math
Arbitrary-precision arithmetic library for PHP
- php
- arbitrary-precision
- biginteger
- bigdecimal
- bigrational
- gmp
- +1 more
+32 stars
from 2,148 · score 3.50
126.trilinos / Trilinos
Primary repository for the Trilinos Project
- snl-science-libs
- sandia-national-laboratories
- hpsf
- scientific-computing
- high-performance-computing
- c-plus-plus
- +2 more
+32 stars
from 1,410 · score 3.50
127.symengine / symengine
SymEngine is a fast symbolic manipulation library, written in C++
- math
- computer-algebra
- c-plus-plus
+31 stars
from 1,395 · score 3.47
+31 stars
from 642 · score 3.47
129.koide3 / fast_gicp
A collection of GICP-based fast point cloud registration algorithms
+30 stars
from 1,674 · score 3.43
130.kexinhuang12345 / DeepPurpose
A Deep Learning Toolkit for DTI, Drug Property, PPI, DDI, Protein Function Prediction (Bioinformatics)
- drug-repurposing
- deep-learning
- drug-target-interactions
- toolkit
- covid19
- virtual-screening
- +13 more
+30 stars
from 1,171 · score 3.43
131.TUDelft-CNS-ATM / bluesky
The open source air traffic simulator
- python
- traffic
- aircraft
- simulation
- air-traffic-control
- air-transport
- +11 more
+30 stars
from 547 · score 3.43
132.RainerKuemmerle / g2o
g2o: A General Framework for Graph Optimization
- g2o
- slam
- c-plus-plus
- graph-optimization
- cpp
+29 stars
from 3,449 · score 3.40
133.psi4 / psi4
Open-Source Quantum Chemistry – an electronic structure package in C++ driven by Python
- quantum-chemistry
- c-plus-plus
- python
- computational-chemistry
- chemistry
- physics
+29 stars
from 1,206 · score 3.40
134.gromacs / gromacs
Public/backup repository of the GROMACS molecular simulation toolkit. Please do not mine the metadata blindly; we use https://gitlab.com/gromacs/gromacs for code review and issue tracking.
+29 stars
from 945 · score 3.40
135.snap-stanford / UCE
UCE is a zero-shot foundation model for single-cell gene expression data
+29 stars
from 322 · score 3.40
136.runmat-org / runmat
Open source math and physics engine that executes MATLAB-syntax code. Features a modern compiler, automatic GPU acceleration for large calculations, and support for math on geometry / FEA calculations.
- matlab
- rust
- jit-compiler
- linear-algebra
- mathematics
- numerical-analysis
- +6 more
+29 stars
from 242 · score 3.40
137.hypre-space / hypre
Parallel solvers for sparse linear systems featuring multigrid methods.
- math-physics
- library
- hpc
- radiuss
+28 stars
from 847 · score 3.37
138.OATML-Markslab / ProteinGym
Official repository for the ProteinGym benchmarks
- benchmark
- computational-biology
- protein
- protein-design
- protein-fitness
+28 stars
from 456 · score 3.37
139.PixarAnimationStudios / OpenSubdiv
An Open-Source subdivision surface library.
+26 stars
from 3,064 · score 3.30
+26 stars
from 588 · score 3.30
+25 stars
from 3,750 · score 3.26
+25 stars
from 1,182 · score 3.26
143.unknown-horizons / godot-port
Unknown Horizons Godot Engine Port
- simulation
- strategy
- game-development
- godot
- gdscript
- game
+25 stars
from 886 · score 3.26
144.scverse / squidpy
Spatial Single Cell Analysis in Python
- single-cell-rna-seq
- single-cell-genomics
- spatial-transcriptomics
- spatial-analysis
- image-analysis
- data-visualization
- +2 more
+25 stars
from 587 · score 3.26
145.DavidArayan / ezy-slice
An open source mesh slicer framework for Unity3D Game Engine. Written in C#.
+24 stars
from 2,257 · score 3.22
146.ethz-adrl / control-toolbox
The Control Toolbox - An Open-Source C++ Library for Robotics, Optimal and Model Predictive Control
- optimal-control
- model-predictive-control
- ilqr
- ilqg
- robotics
- trajectory-optimization
- +9 more
+24 stars
from 1,698 · score 3.22
147.Aceinna / gnss-ins-sim
Open-source GNSS + inertial navigation, sensor fusion simulator. Motion trajectory generator, sensor models, and navigation
- inertial-navigation-systems
- gnss
- gps
- imu
- integrated-navigation
+24 stars
from 1,474 · score 3.22
148.suyashkumar / dicom
⚡High Performance DICOM Medical Image Parser in Go.
- dicom
- dicom-images
- golang
- golang-library
- golang-package
- parser
- +10 more
+24 stars
from 1,072 · score 3.22
149.ahmedfgad / GeneticAlgorithmPython
Source code of PyGAD, a Python 3 library for building the genetic algorithm and training machine learning algorithms (Keras & PyTorch).
- python
- genetic-algorithm
- optimization
- numpy
- pygad
- pygad-documentation
- +4 more
+23 stars
from 2,211 · score 3.18
150.vqdang / hover_net
Simultaneous Nuclear Instance Segmentation and Classification in H&E Histology Images.
+23 stars
from 733 · score 3.18
151.firedrakeproject / firedrake
Firedrake is an automated system for the portable solution of partial differential equations using the finite element method (FEM)
+23 stars
from 658 · score 3.18
152.nasa / trick
Trick Simulation Environment. Trick provides a common set of simulation capabilities and utilities to build simulations automatically.
+23 stars
from 157 · score 3.18
153.elixir-nx / nx
Multi-dimensional arrays (tensors) and numerical definitions for Elixir
+22 stars
from 2,898 · score 3.14
154.pydata / numexpr
Fast numerical array expression evaluator for Python, NumPy, Pandas, PyTables and more
+22 stars
from 2,523 · score 3.14
155.DTolm / VkFFT
Vulkan/CUDA/HIP/OpenCL/Level Zero/Metal Fast Fourier Transform library
+22 stars
from 1,765 · score 3.14
156.NetTopologySuite / NetTopologySuite
A .NET GIS solution that is fast and reliable for the .NET platform.
- topology
- nts
- sfs
- c-sharp
- library
- jts
- +1 more
+22 stars
from 1,706 · score 3.14
+22 stars
from 1,342 · score 3.14
158.PyWavelets / pywt
PyWavelets - Wavelet Transforms in Python
- wavelets
- wavelet-transform
- signal-processing
- image-processing
- continuous-wavelet
+21 stars
from 2,391 · score 3.09
159.mahmoodlab / CONCH
Vision-Language Pathology Foundation Model - Nature Medicine
- bioimage-analysis
- bioimage-informatics
- conch
- foundation-model
- health-informatics
- histopathology
- +9 more
+21 stars
from 519 · score 3.09
160.ericstoneking / 42
Simulation for spacecraft attitude control system analysis and design
+21 stars
from 446 · score 3.09
161.arrayfire / arrayfire
ArrayFire: a general purpose GPU library.
+20 stars
from 4,888 · score 3.04
162.dpilger26 / NumCpp
C++ implementation of the Python Numpy library
- python
- numpy
- c-plus-plus
- numerical-analysis
- scientific-computing
- algorithms
- +3 more
+20 stars
from 3,948 · score 3.04
163.gradientspace / geometry3Sharp
C# library for 2D/3D geometric computation, mesh algorithms, and so on. Boost license.
+20 stars
from 1,884 · score 3.04
+20 stars
from 411 · score 3.04
165.Rolf-Hempel / PlanetarySystemStacker
Produce a sharp image of a planetary system object (moon, sun, planets) from many seeing-affected frames according to the "lucky imaging" technique.
+20 stars
from 327 · score 3.04
166.prov-gigapath / prov-gigapath
Prov-GigaPath: A whole-slide foundation model for digital pathology from real-world data
+19 stars
from 626 · score 3.00
167.cdk / cdk
The Chemistry Development Kit
- code4lib
- chemistry
- java
- cheminformatics
- bioinformatics
- blueobelisk
+19 stars
from 593 · score 3.00
+19 stars
from 581 · score 3.00
169.arneschneuing / DiffSBDD
A Euclidean diffusion model for structure-based drug design.
- ddpm
- drug-design
- equivariance
- generative-model
- graph-neural-networks
- machine-learning
+19 stars
from 518 · score 3.00
170.hms-dbmi / viv
Library for multiscale visualization of high-resolution multiplexed bioimaging data on the web. Directly renders Zarr and OME-TIFF.
- hubmap
- imaging
- openmicroscopy
- ome-tiff
- zarr
- viv
- +1 more
+19 stars
from 354 · score 3.00
171.CSOgroup / cellcharter
A Python package for the identification, characterization and comparison of spatial clusters from spatial -omics data.
+19 stars
from 185 · score 3.00
172.xtensor-stack / xtensor
C++ tensors with broadcasting and lazy computing
- c-plus-plus-14
- numpy
- multidimensional-arrays
- tensors
- c-plus-plus-17
- c-plus-plus-20
- +1 more
+18 stars
from 3,752 · score 2.94
173.marcomusy / vedo
A python module for scientific analysis of 3D data based on VTK and Numpy
- 3d-graphics
- vtk
- 3d
- mesh
- simulations
- scientific-visualization
- +5 more
+18 stars
from 2,257 · score 2.94
174.libtom / libtommath
LibTomMath is a free open source portable number theoretic multiple-precision integer library written entirely in C.
- mpi
- libtommath
- c
- math
- multi-precision
+18 stars
from 795 · score 2.94
175.ginkgo-project / ginkgo
Numerical linear algebra software package
- linear-algebra
- hpc
- gpu-computing
- cuda
- krylov-methods
- preconditioning
- +6 more
+18 stars
from 612 · score 2.94
176.dan2097 / opsin
Open Parser for Systematic IUPAC Nomenclature. Chemical name to structure conversion
+18 stars
from 227 · score 2.94
177.autodiff / autodiff
automatic differentiation made easier for C++
- automatic-differentiation
- auto-differentiation
- autodiff
- autodifferentiation
- differentiation
- derivatives
- +1 more
+17 stars
from 1,946 · score 2.89
178.samtools / htslib
C library for high-throughput sequencing data formats
- htslib
- bioinformatics
- sam
- bam
- cram
- vcf
- +2 more
+17 stars
from 939 · score 2.89
179.jwiegley / category-theory
An axiom-free formalization of category theory in Coq for personal study and practical work
- category-theory
- coq
- monad
- profunctor
- comonads
- monoid
- +7 more
+17 stars
from 802 · score 2.89
180.chris-mcginnis-ucsf / DoubletFinder
R package for detecting doublets in single-cell RNA sequencing data
+17 stars
from 557 · score 2.89
181.Teichlab / celltypist
A tool for semi-automatic cell type classification
- python
- single-cell
- machine-learning
- scrna-seq
- cell-type-classification
- label-transfer
+17 stars
from 500 · score 2.89
182.facebookresearch / esmArchived
Evolutionary Scale Modeling (esm): Pretrained language models for proteins
+16 stars
from 4,160 · score 2.83
+16 stars
from 1,133 · score 2.83
184.invesalius / invesalius3
3D medical imaging reconstruction software
- dicom
- dicom-viewer
- magnetic-resonance-imaging
- medical-image-processing
- medical-imaging
- segmentation
- +2 more
+16 stars
from 799 · score 2.83
185.mdtraj / mdtraj
An open library for the analysis of molecular dynamics trajectories
- molecular-dynamics
- python
- mdtraj
- rmsd
- dihedral-angles
- pdb
- +2 more
+16 stars
from 727 · score 2.83
186.aurora-opensource / au
A C++14-compatible physical units library with no dependencies and a single-file delivery option. Emphasis on safety, accessibility, performance, and developer experience.
- cpp
- cpp14
- cpp14-library
- dimensional-analysis
- physical-quantities
- quantity
- +11 more
+16 stars
from 433 · score 2.83
187.auto-differentiation / xad
The fastest automatic differentiation library for C++, with Python bindings. Forward, adjoint and higher-order derivatives, checkpointing, Eigen support and JIT. Reproducible benchmarks against CppAD, Adept and autodiff.
- automatic-differentiation
- aad
- algorithmic-differentiation
- autodiff
- adjoint
- cpp
- +13 more
+16 stars
from 424 · score 2.83
188.oemof / oemof-solph
A model generator for energy system modelling and optimisation (LP/MILP).
- energy
- energy-system
- modelling
- modelling-framework
+16 stars
from 410 · score 2.83
189.dcjones / proseg
Probabilistic cell segmentation for in situ spatial transcriptomics
+16 stars
from 182 · score 2.83
190.pmp-library / pmp-library
The Polygon Mesh Processing Library
- mesh-processing
- geometry-processing
- polygon-mesh
- triangle-mesh
- c-plus-plus
- surface-mesh
- +9 more
+15 stars
from 1,495 · score 2.77
191.owlbarn / owl
Owl - OCaml Scientific Computing @ https://ocaml.xyz
- matrix
- linear-algebra
- ndarray
- statistical-functions
- topic-modeling
- regression
- +14 more
+15 stars
from 1,343 · score 2.77
192.fo-dicom / fo-dicom
Fellow Oak DICOM for .NET, .NET Core, Universal Windows, Android, iOS, Mono and Unity
- dicom
- netcore
- medical
- medical-imaging
- dot-net
- c-sharp
- +4 more
+15 stars
from 1,205 · score 2.77
193.jarun / bcal
:1234: Bits, bytes and general-purpose calculator
- storage
- storage-unit-converter
- command-line
- standalone
- terminal
- calculator
- +6 more
+15 stars
from 693 · score 2.77
+14 stars
from 1,840 · score 2.71
195.NVIDIA / MatX
An efficient C++20 GPU numerical computing library with Python-like syntax
+14 stars
from 1,437 · score 2.71
196.hail-is / hail
Cloud-native genomic dataframes and batch computing
- genetics
- vcf
- genomics
- gwas
- bioinformatics
- python
- +2 more
+14 stars
from 1,068 · score 2.71
197.DedalusProject / dedalus
A flexible framework for solving PDEs with modern spectral methods.
- spectral-methods
- fluid-dynamics
- pde-solver
+14 stars
from 699 · score 2.71
198.softwareQinc / qpp
Modern C++ quantum computing library
- quantum-computing
- c-plus-plus
- cpp
- cpp11
- quantum
- simulator
- +2 more
+14 stars
from 664 · score 2.71
199.datamol-io / datamol
Molecular Processing Made Easy.
- python
- molecule
- rdkit
- drug-discovery
- drug-design
- molecules
- +2 more
+14 stars
from 542 · score 2.71
+14 stars
from 384 · score 2.71