+324 stars
from 8,397 · score 5.78
Trending repositories
Ranked by Attention Score: stars gained over the last 90 complete days
38 repositories by Attention Score · Aug 6, 2026 – Nov 3, 2026 (UTC)
2.deepchem / deepchem
Democratizing Deep-Learning for Drug Discovery, Quantum Chemistry, Materials Science and Biology
- drug-discovery
- quantum-chemistry
- deep-learning
- biology
- materials-science
- hacktoberfest
+232 stars
from 6,891 · score 5.45
+203 stars
from 14,723 · score 5.32
4.jwohlwend / boltz
Official repository for the Boltz biomolecular interaction models
- binding-prediction
- drug-discovery
- protein-structure
+156 stars
from 4,133 · score 5.06
5.Biohub / esm
The repository host gives no description.
+136 stars
from 2,877 · score 4.92
+125 stars
from 2,994 · score 4.84
7.biopython / biopython
Official git repository for Biopython (originally converted from CVS)
- python
- bioinformatics
- genomics
- biopython
- protein
- protein-structure
- +3 more
+117 stars
from 5,140 · score 4.77
8.ClawBio / ClawBio
🦖 ClawBio - The first bioinformatics-native AI agent skill library. Local-first. Reproducible. Open. Free.
- ai-agents
- bioinformatics
- equity
- genomics
- local-first
- openclaw
- +2 more
+97 stars
from 1,075 · score 4.58
+86 stars
from 1,812 · score 4.47
+57 stars
from 1,606 · score 4.06
11.evo-design / evo
Biological foundation modeling from molecular to genome scale
+55 stars
from 1,531 · score 4.03
+54 stars
from 2,227 · score 4.01
13.scverse / scvi-tools
Deep probabilistic analysis of single-cell and spatial omics data
- scrna-seq
- variational-bayes
- variational-autoencoder
- cite-seq
- single-cell-genomics
- single-cell-rna-seq
- +4 more
+53 stars
from 1,667 · score 3.99
14.aqlaboratory / openfold
Trainable, memory-efficient, and GPU-friendly PyTorch reproduction of AlphaFold 2
- pytorch
- protein-structure
- alphafold2
+45 stars
from 3,404 · score 3.83
15.mims-harvard / PrimeKG
Precision Medicine Knowledge Graph (PrimeKG)
- knowledge-graph
- precision-medicine
- therapeutics
- bioinformatics
- dataset
- graph-machine-learning
- +2 more
+37 stars
from 801 · score 3.64
16.chaidiscovery / chai-lab
Chai-1, SOTA model for biomolecular structure prediction
+36 stars
from 1,971 · score 3.61
17.RosettaCommons / RoseTTAFold
This package contains deep learning models and related scripts for RoseTTAFold
+33 stars
from 2,247 · score 3.53
18.instadeepai / nucleotide-transformer
Foundation Models for Genomics & Transcriptomics
- genomics
- deep-learning
- transformer
- dna
- foundation-models
- transcriptomics
- +1 more
+31 stars
from 903 · score 3.47
19.kexinhuang12345 / DeepPurpose
A Deep Learning Toolkit for DTI, Drug Property, PPI, DDI, Protein Function Prediction (Bioinformatics)
- drug-repurposing
- deep-learning
- drug-target-interactions
- toolkit
- covid19
- virtual-screening
- +13 more
+30 stars
from 1,171 · score 3.43
20.samtools / htslib
C library for high-throughput sequencing data formats
- htslib
- bioinformatics
- sam
- bam
- cram
- vcf
- +2 more
+18 stars
from 939 · score 2.94
21.facebookresearch / esmArchived
Evolutionary Scale Modeling (esm): Pretrained language models for proteins
+16 stars
from 4,159 · score 2.83
22.hail-is / hail
Cloud-native genomic dataframes and batch computing
- genetics
- vcf
- genomics
- gwas
- bioinformatics
- python
- +2 more
+14 stars
from 1,068 · score 2.71
23.microsoft / evodiff
Generation of protein sequences and evolutionary alignments via discrete diffusion models
- discrete-diffusion
- generative-model
- multiple-sequence-alignment
- protein-sequences
+14 stars
from 676 · score 2.71
24.jerryji1993 / DNABERT
DNABERT: pre-trained Bidirectional Encoder Representations from Transformers model for DNA-language in genome
- kmer
- dnabert-model
- kmer-format
- gpu
- sequence
- genome
- +4 more
+13 stars
from 770 · score 2.64
25.HazyResearch / hyena-dna
Official implementation for HyenaDNA, a long-range genomic foundation model built with Hyena
- foundation-models
- genomics
- language-models
+11 stars
from 796 · score 2.48
26.agemagician / ProtTrans
ProtTrans is providing state of the art pretrained language models for proteins. ProtTrans was trained on thousands of GPUs from Summit and hundreds of Google TPUs using Transformers Models.
+9 stars
from 1,314 · score 2.30
27.vcflib / vcflib
C++ library and cmdline tools for parsing and manipulating VCF files with python and zig bindings
- variant-calling
- genomics
- vcf-manipulation
- genotyping
- haplotypecaller
+8 stars
from 681 · score 2.20
28.broadinstitute / cromwell
Scientific workflow engine designed for simplicity & scalability. Trivially transition between one off use cases to massive scale production environments
- workflow-execution
- workflow
- cloud
- hpc
- bioinformatics
- executor
- +7 more
+7 stars
from 1,076 · score 2.08
29.bigdatagenomics / adam
ADAM is a genomics analysis platform with specialized file formats built using Apache Avro, Apache Spark, and Apache Parquet. Apache 2 licensed.
- spark
- big-data
- bioinformatics
- genomics
- parquet
- avro
- +4 more
+6 stars
from 1,054 · score 1.95
30.YuLab-SMU / ggtree
:christmas_tree:Visualization and annotation of phylogenetic trees
- r
- visualization
- phylogenetic-trees
- annotations
- ggplot2
+6 stars
from 929 · score 1.95
31.songlab-cal / tape
Tasks Assessing Protein Embeddings (TAPE), a set of five biologically relevant semi-supervised learning tasks spread across different domains of protein biology.
- deep-learning
- protein-sequences
- protein-structure
- semi-supervised-learning
- benchmark
- language-modeling
- +2 more
+6 stars
from 740 · score 1.95
32.awslabs / dgl-lifesci
Python package for graph neural networks in chemistry and biology
- deep-learning
- graph-neural-networks
- dgl
- cheminformatics
- bioinformatics
- geometric-deep-learning
- +2 more
+5 stars
from 807 · score 1.79
33.bebop / poly
A Go package for engineering organisms.
- synthetic-biology
- synbio
- genetic-engineering
- molecular-biology
- bioengineering
- computational-biology
- +14 more
+5 stars
from 731 · score 1.79
+5 stars
from 703 · score 1.79
35.dib-lab / khmer
In-memory nucleotide sequence k-mer counting, filtering, graph traversal and more
- dna
- k-mer
- python
- bloom-filter
- count-min-sketch
- graph-traversal
- +1 more
+4 stars
from 787 · score 1.61
36.txWang / MOGONET
MOGONET (Multi-Omics Graph cOnvolutional NETworks) is a novel multi-omics data integrative analysis framework for classification tasks in biomedical applications.
+3 stars
from 186 · score 1.39
37.bcbio / bcbio-nextgen
Validated, scalable, community developed variant calling, RNA-seq and small RNA analysis
+2 stars
from 1,028 · score 1.10
38.sqjin / CellChatArchived
R toolkit for inference, visualization and analysis of cell-cell communication from single-cell data
- cell-cell-communication
- single-cell-analysis
- cell-cell-interaction
- microenvironment
+1 stars
from 788 · score 0.69